| 1 |
Modulation of BOLD response in motion sensitive lateral temporal cortex by real and fictive motion sentences
|
|
|
|
In: http://crl.ucsd.edu/newsletter/Publications/Saygin_McCulluogh_Emmorey_JCN_2010.pdf (2010)
|
|
BASE
|
|
Show details
|
|
|
| 2 |
What is involved and what is necessary for complex linguistic and nonlinguistic auditory processing: Evidence from functional magnetic resonance imaging and lesion data
|
|
|
|
In: http://eprints.ucl.ac.uk/3670/1/3670.pdf (2007)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Grammaticality Judgment under Non-Optimal Processing Conditions: Deficits induced in normal participants resemble those observed in aphasic patients
|
|
|
|
In: http://crl.ucsd.edu/~saygin/papers/tjudgedegabs.pdf (2003)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Voxel-based lesion-symptom mapping.
|
|
|
|
In: https://crl.ucsd.edu/%7Esaygin/papers/vlsm_nn03.pdf (2003)
|
|
Abstract:
For more than a century, lesion-symptom mapping studies have yielded valuable insights into the relationships between brain and behavior, but newer imaging techniques have surpassed lesion analysis in examining functional networks. Here we used a new method-voxel-based lesion-symptom mapping (VLSM)-to analyze the relationship between tissue damage and behavior on a voxel-by-voxel basis, as in functional neuroimaging. We applied VLSM to measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients: the VLSM maps for these measures confirm the anticipated contrast between anterior and posterior areas, and they also indicate that interacting regions facilitate fluency and auditory comprehension, in agreement with findings from modern brain imaging. Localization of cognitive processes through lesion analysis continues to reveal new information about brain-behavior relationships in patient populations Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies in normal adults have produced a host of new findings that have refined previous lesion-based models of neural organization We analyzed data on speech fluency and language comprehension for 101 left-hemisphere-injured stroke patients who showed some degree of speech or language impairment. Dissociations between speech production and comprehension have had an important role in the history of aphasiology. For this reason, we focused on the fluency and auditory comprehension subtests of a standard assessment tool, the Western Aphasia Battery (WAB) This anterior-posterior contrast for fluency versus comprehension is consistent with historical findings in aphasia. However, the regions typically associated with these deficits (Brodmann areas (BA) 44 and 45 in the inferior frontal gyrus (Broca's area) for fluency; posterior BA 22 in the superior temporal gyrus (Wernicke's area) for comprehension), were not the areas most reliably associated with deficits. In fact, the regions with the highest t-scores were the middle temporal areas, previously implicated in lesion 12 and fMRI 8,13 studies of auditory comprehension, inferior parietal and dorsolateral prefrontal cortex, implicated recently in sentence comprehension 12 , and the left anterior insula, identified as a region important for speech production through lesion analysis 2 and recent PET studies In lesion studies, an area may emerge as relevant either because it has a direct causal role or because of a diaschitic effect involving highly correlated lesions some distance away. Indeed, the apparent role of the insula in fluency could be an indirect consequence of lesions to Broca's area, and the role of the middle temporal gyrus in comprehension could be a consequence of lesions to Wernicke's area. VLSM can be used to test hypotheses such as these. Based on anatomical criteria, we identified central voxels in four a priori ROIs: Broca's area, the anterior insula, Wernicke's area and the middle temporal gyrus. We constructed four maps factoring out the effects of these voxels by carrying out analyses of covariance (ANCOVAs) at all other voxels using the state (intact or lesioned) of each voxel of interest as the covariates With VLSM, similarity between statistical maps can be assessed by calculating the correlation between t-scores on two tasks, treating voxels as subjects. When fluency and auditory comprehension were compared in this manner, a correlation of 0.59 was obtained (see Here we used a new technique to analyze lesion-symptom relationships in a large group of left-hemisphere-lesioned patients, using behavioral data from two well-studied tasks: fluency and language comprehension. VLSM is an improvement on previous lesion-symptom mapping techniques because it uses all available information, eliminating reliance on cutoff scores, clinical diagnoses or specified regions of interest. Thus, it allows for additional areas to emerge in the exploration of networks that support a given behavior. As such, it also serves as a bridge between classic approaches to lesion-symptom mapping and modern functional imaging. Note: Supplementary information is available on the Nature Neuroscience website.
|
|
URL: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.7765
|
|
BASE
|
|
Hide details
|
|
|
| 5 |
Pragmatics in Human-Computer Conversations
|
|
|
|
In: http://crl.ucsd.edu/~saygin/papers/saygin-jop.pdf (2002)
|
|
BASE
|
|
Show details
|
|
|
| 6 |
Processing figurative language in a multi-lingual task: Translation, transfer and metaphor
|
|
|
|
In: http://crl.ucsd.edu/~saygin/papers/corplingpaper.pdf (2001)
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Turing Test: 50 years later
|
|
|
|
In: http://www.cs.bilkent.edu.tr/~ilyas/PDF/minds2000.pdf (1999)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Neural Resources for Processing Language and Environmental Sounds: Evidence from aphasia
|
|
|
|
In: http://crl.ucsd.edu/~saygin/papers/Saygin03Brain.pdf
|
|
BASE
|
|
Show details
|
|
|
| 9 |
RUNNING TITLE: LANGUAGE AND THE BRAIN Language and the Brain
|
|
|
|
In: http://www.alphalab.psyc.bbk.ac.uk/Publications/LizFestscriftChaptLangBrain.pdf
|
|
BASE
|
|
Show details
|
|
|
| 10 |
FORUM LANGUAGE IN AN EMBODIED BRAIN: THE ROLE OF ANIMAL MODELS
|
|
|
|
In: http://crl.ucsd.edu/~saygin/papers/cortexforum04.pdf
|
|
BASE
|
|
Show details
|
|
|
|
|
